tyrosinekinaseinhibitor相关论文
慢性粒细胞白血病（CML）靶向药物-酪氨酸激酶抑制剂（TKI）的应用极大改善了CML患者的预后。但TKI不间断的治疗影响患者的生命质量、加重......
在酪氨酸激酶抑制剂（TKI）治疗时代，慢性粒细胞白血病（CML）已具有“慢病化管理”的趋势。虽然四代TKI药物相继出现，但是CML的治疗需求仍有......
分析郑州大学附属肿瘤医院采用Bcl-2抑制剂维奈托克联合酪氨酸激酶抑制剂（TKI）及含地塞米松小剂量化疗方案治疗5例复发/难治（R/R）费城......
目的:分析单中心肺腺癌脑膜转移患者的预后并探讨其影响因素。方法:回顾性分析河南省人民医院神经内科自2010年1月至2021年6月诊治......
目的 The expression of ATP-binding cassette subfamily G member 2(ABCG2)in manycancers was correlated with development of......
Pirotinib, a novel pan-ErbR inhibitor, is highly effective against gastric adenocarcinoma in preclin
Objective: Despite the improved patient care and the declined mortality rate, gastric cancer is still a leading cause of......
A validation LC-MS/MS method for quantification of erlotinib in human plasma and its application for
The object of this study was to develop and validate a simple and reliable LC-MS/MS method for quantitation of erlotinib......
Survival analysis of non-small cell lung cancer using TKI treatment-- A multi-center retrospective s
Objective: To assess differences in overall survival among patients with NSCLC using TKIs in first or second line treatm......
Blockade of methylation enhances the therapeutic effect of gefitinib in non-small cell lung cancer c
Background: The sensitivity of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) ha......
ABCB1-mediated multidrug resistance (MDR) remains a major obstacle to successful chemotherapy in ovarian cancer. Herein,......
The development of new cancer chemotherapies has been improving the prognosis of patients with cancer.Indeed, age-standa......
Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekee
Objective Like T315I Bcr-Abl, T674I FIP1L1-PDGFRα existed in a subset of chronic eosinophilic leukemia (CEL) is also ga......
The Radiosensitizing Effects of TKI at Different Administration Schedules are Related to PI3K Signal
The optimal administration time when tyrosine kinase inhibitor (TKI) combined with radiotherapy is unclear until today.T......
Screening and research selective anti-hepatoma drugs from the traditional Chuang and Yao medicine in
AIM To screen and research targeting anti-hepatoma drugs from 18 kinds of the traditional Chinese herbal medicines from ......
Chemotherapy and EGFR-tyrosine Kinase Inhibitors in The Treatment of Non-small Cell Lung Cancer with
[Purpose] Chemotherapy and epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKIs) treatments remain under......
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慢性粒细胞白血病(CML)具有特异性的细胞遗传学改变，形成的BCR-ABL融合基因表达相对分子质量为210 kD的蛋白P210。随着分子生物学等......
费城染色体样急性淋巴细胞白血病(Ph-like ALL)是一组基因表达谱与费城染色体阳性ALL(Ph+ALL)相似的B-ALL(B-lineage ALL)亚群,涉......
Effects of epidermal growth factor and its signal transduction inhibitors on apoptosis in human colo
AIM: The study investigated if EGF signaling inhibitors, EGF antibody and tyrphostin 51 (a tyrosine kinase inhibitor),me......
Expression of c-kit receptor in human cholangiocarcinoma and in vivo treatment with imatinib mesilat
AIM: To investigate the c-kit expression in biliary tract cancer cell lines and histological sections from patients with......
AIM:To investigate in vitro treatment with NVPAEW541,a small molecule inhibitor of insulin-like growth factor-1 receptor......
吉非替尼、厄洛替尼、阿法替尼和奥希替尼已被推荐为表皮生长因子受体突变的晚期非小细胞肺癌的一线治疗药物,但同时比较这四种酪......
目的 探讨吉非替尼获得性耐药细胞株对不同化疗药物的敏感性,为分子靶向治疗失败的患者选择化疗方案提供临床前的依据.方法 体外培......
